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KMID : 0665220090220020302
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Korean Journal of Food and Nutrition
2009 Volume.22 No. 2 p.302 ~ p.307
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Effect of Dioscorea rhizome on the Activity of Intestinal Disaccharidases in Diabetic db/db mice
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Lee Tae-Ho
Kim Sun-Yeou
Lee Pyeong-Jae
Son Mi-Won
Choi Sang-Zin
Ha Sang-Keun
Kang Dong-Ho
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Abstract
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The present study was designed to clarify the antidiabetic activity and mechanism of Dioscorea rhizome in diabetic db/db mice. Mice were administered Dioscorea rhizome and rosiglitazone orally for 7 weeks and the effects of these compounds on fasting blood glucose, glucose tolerance and intestinal disaccharidase activity in db/db mice were evaluated. The fasting serum glucose of the D. rhizome treated group was reduced when compared with that of the db/db control group. In addition, the disaccharidase activities in homogenates of the proximal, middle and distal segment of the small intestine were significantly decreased response to D. rhizome treatment, especially in the middle segment. These results suggest that D. rhizome decreases blood glucose via a decrease in the activity of disaccharidase in the mucosa of the middle region of the small intestine in db/db mice.
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KEYWORD
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disaccharidase, hypoglycemic effect, glucose tolerance, Dioscorea japonica
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